Pharmacogenomics-enriched comprehensive medication management has the power to catch these potential serious interactions and provide alternatives. Between 19, the proportion of adult patients at risk for severe drug-drug interactions was more than 13% 12. Studies indicate that implementing a pharmacogenomics-enriched comprehensive medication management program can save a patient $4,000 annually, simply by optimizing medication regimens 9,10.Īnother area where pharmacogenomics is distinctively advantageous is for patients that take multiple medications simultaneously which has increased in recent years with aging populations 11. More than half of patients fail to achieve remission with the first pharmacologic therapy 8. The pharmacologic treatment of mental health conditions is complex because front-line drugs like SSRIs take significant time to produce effects. In 2020, nearly 17% of adults took pills to treat mental health conditions. Mental health is a field in which the value of pharmacogenomics has significant potential. And the total healthcare cost resulting from non-adherence can range anywhere from $949 to $44,190 per person 7. In fact, they were estimated to be the fourth leading cause of death in the United States before the COVID-19 pandemic 6. And since a medication adherence of at least 80% is generally necessary for therapeutic efficacy 4, adverse drug reactions are a significant contributor to morbidity and mortality. In addition, experiencing adverse side effects is one of the most common reasons that on average, 50% of patients are non-adherent to their medication 5. And from 2009 to 2012, approximately half of patients in the United States were exposed to one or more drugs for which pharmacogenomic guidelines are known 3.Īpprox 1/2 of patients were exposed to one or more drugs for which pharmacogenomic guidelines are known Of these drug-gene pairs, 87% impact safety, and efficacy. Food and Drug Administration (FDA) currently lists over 300 drug-gene pairs to aid prescribers in making decisions based on genetic test results 2. Implementing a genomics program that includes access to pharmacogenomics is critical for health systems to be able to accomplish it. The Quadruple Aim-enhancing patient experience, increasing provider satisfaction, improving population health, and reducing costs of care-serves as a guide for optimal health system performance 1.
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